Joshua Trachenberg's lab is interested in the molecular and cellular processes of sensory processing and memory and on the connections between these two fundamental processes. They are also investigating how specific developmental disorders such as autism, alter these process. The focus is on the molecular and synaptic mechanisms of cortical plasticity, using the primary visual cortex as a model system. The lab is determining where experience-dependent plasticity is initiated in the cortical circuitry, how experience regulates the growth or retraction of synapses, and how plasticity mechanisms change with age.
Lab Web site
Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits.
Peñagarikano O, Abrahams BS, Herman EI, Winden KD, Gdalyahu A, Dong H, Sonnenblick LI, Gruver R, Almajano J, Bragin A, Golshani P, Trachtenberg JT, Peles E, Geschwind DH.
Cell. 2011 Sep 30;147(1):235-46.
Fast-spiking interneurons have an initial orientation bias that is lost with vision.
Kuhlman SJ, Tring E, Trachtenberg JT.
Nat Neurosci. 2011 Jul 12;14(9):1121-3. doi: 10.1038/nn.2890.
The refinement of ipsilateral eye retinotopic maps is increased by removing the dominant contralateral eye in adult mice.
Smith SL, Trachtenberg JT.
PLoS One. 2010 Mar 29;5(3):e9925.
MDL constrained 3-D grayscale skeletonization algorithm for automated extraction of dendrites and spines from fluorescence confocal images.
Yuan X, Trachtenberg JT, Potter SM, Roysam B.
Neuroinformatics. 2009 Dec;7(4):213-32. Epub 2009 Dec 11.
Delta-catenin is required for the maintenance of neural structure and function in mature cortex in vivo.
Matter C, Pribadi M, Liu X, Trachtenberg JT.
Neuron. 2009 Nov 12;64(3):320-7.