The Silva laboratory is studying the biology of learning and memory. They are interested in the molecular, cellular and circuit processes that underlie the allocation, encoding and storage of information. To accomplish this they are using a variety of techniques including sophisticated molecular genetic approaches, optical physiology, optogenetics, in vivo imaging and behavioral analysis.
Silva and colleagues have also studied the impact of these mechanisms in animal models of cognitive disorders, including intellectual disabilities. Based on these mechanistic studies, they have developed treatments for Neurofibromatosis type I and Tuberous Sclerosis, that are currently being tested in clinical trials. The Silva laboratory is also developing bioinformatic strategies for tracking and planning experiments (researchmaps.org).
Shilyansky C, Karlsgodt KH, Cummings DM, Sidiropoulou K, Hardt M, James AS, Ehninger D, Bearden CE, Poirazi P, Jentsch JD, Cannon TD, Levine MS, Silva AJ. Neurofibromin regulates corticostriatal inhibitory networks during working memory performance. Proc Natl Acad Sci U S A. 2010 Jul 12. PMID: 20624961
Ehninger, D., Y. Sano, P.J. de Vries, K. Dies, D. Franz, D.H. Geschwind, M. Kaur, Y.S. Lee, W. Li, J.K. Lowe, J.A. Nakagawa, M. Sahin, K. Smith, V. Whittemore, and A.J. Silva, Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice. Molecular Psychiatry, 2012. 17(1): p. 62-70. PMID: 21079609
Zhou, M, Li, W, Huang, S, Song, J, Kim, J Tian, X, Kang, E Sano, Y, Liu, C, Balaji, J, Wu, S, Zhou, Y, Zhou, Y, Parivash, S, Ehninger, D, He, L. Song, H, 3, Ming, G, Silva AJ mTOR Inhibition Ameliorates Cognitive and Affective Deficits Caused by Disc1 Knockdown Specifically in Adult-Born Dentate Granule Neurons. Neuron 77, 647–654, 2013 PMID: 23439118
Landreth, A. and Silva, A.J. The Need for Research Maps to Navigate Published Work and Inform Experiment Planning. Neuron 2013 79 411-415 PMID: 23931992
Rogerson, T, Cai, D, Frank, A, Sano, Y, Shobe, J, Aranda, ML, Silva, AJ Synaptic Tagging During Memory Allocation. Nature Reviews Neuroscience 15, 157–169 (2014) PMID: 24496410
Czajkowski, R, Jayaprakash, B, Wiltgen, B, Rogerson, T, Karlsson, MG, Barth, A, Trachtenberg, J, and Silva, AJ. Encoding and storage of spatial information in the retrosplenial cortex, PNAS Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8661-6 PMID: 24912150
Lee, Y-S, Ehninger, D, Zhou, M, Oh, J-Y, Butz, D, Araki, T, Nam, CI, Balaji, J, Sano, Y, Amin, A, Kim, H, Burger, C, Neel, BG, and Silva, AJ. Mechanism and treatment for the learning and memory deficits associated with mouse models of Noonan syndrome, Nature Neuroscience 17, 1736–1743 (2014); PMID: 25383899
Sano, Y, Shobe, JL, Zhou, M, Huang, S, Cai, DJ, Roth, BL, Kamata, M, and Silva, AJ. CREB regulates memory allocation in the insular cortex. Curr Biol. 2014 Nov 13;24(23):2833-283 (2014) PMID: 25454591
Silva AJ, Müller KR. The need for novel informatics tools for integrating and planning research in molecular and cellular cognition. Learn Mem. 2015 Aug 18;22(9):494-8. PMID: 26286658
Engineering the next revolution in neuroscience: the new science of experiment planning, 2013 by Alcino J. Silva, Anthony Landreth, John Bickle. Oxford Press, ISBN-13: 978-0199731756 ISBN-10: 0199731756 Edition: 1st