Thomas O’Dell's lab is investigating the synaptic and molecular mechanisms involved in learning and memory formation in the mammalian central nervous system. They use electrophysiological, pharmacological, and molecular genetic (transgenic mice) approaches to decipher the molecular components of the biochemical pathways responsible for memory formation in the mammalian brain.
Fear learning and extinction are linked to neuronal plasticity through Rin1 signaling.
Bliss JM, Gray EE, Dhaka A, O'Dell TJ, Colicelli J.
J Neurosci Res. 2010 Mar;88(4):917-26.
Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity.
Carlisle HJ, Fink AE, Grant SG, O'Dell TJ.
J Physiol. 2008 Dec 15;586(Pt 24):5885-900. Epub 2008 Oct 20.
Long-term potentiation in the hippocampal CA1 region does not require insertion and activation of GluR2-lacking AMPA receptors.
Gray EE, Fink AE, Sariñana J, Vissel B, O'Dell TJ.
J Neurophysiol. 2007 Oct;98(4):2488-92. Epub 2007 Jul 25.
Long-term potentiation persists in an occult state following mGluR-dependent depotentiation.
Delgado JY, O'dell TJ.
Neuropharmacology. 2005 Jun;48(7):936-48.
Phosphorylation of proteins involved in activity-dependent forms of synaptic plasticity is altered in hippocampal slices maintained in vitro.
Ho OH, Delgado JY, O'Dell TJ.
J Neurochem. 2004 Dec;91(6):1344-57.