The Mathews' lab uses a multifaceted approach to understand the role of the cerebellum in learning and memory. Using in vivo and in vitro electrophysiology, fMRI, and behavioral techniques in rodent models the goal of the lab is to understand how modifications to the cerebellar circuit underlies learning at a cellular and systems level.
Lee, K.H., Mathews, P., Reeves, A., Choe, K., Jami, S., Serrano, R., Otis, T. (2015) Circuit mechanisms underlying motor memory formation in the cerebellum. Neuron, 86(2):529-540
Otis, T., Mathews, P., Lee, K.H., Maiz, J. (2012) How do climbing fibers teach? Front. Neural Circuits., 6(95):1-3
Mathews, P., Lee, K.H., Peng, Z., Houser, C., Otis, T. (2012) Effects of climbing fiber driven inhibition on Purkinje neuron spiking. J. Neurosci., 32(50):17988-997
Mathews, P., Jercog, P., Rinzel, J., Scott, L., Golding, N. (2010) Control of submillisecond synaptic timing in binaural coincidence detectors via a somatically directed gradient of Kv1 channels. Nat. Neurosci., 13(5):601-9
Scott, L.*, Mathews, P., Golding, N. (2010) Perisomatic voltage-gated sodium channels actively maintain linear synaptic integration in principal neurons of the medial superior olive. J. Neurosci., 30(6):2039-50
Scott, L.*, Mathews, P., Golding, N. (2005) Post-hearing developmental refinement of temporal processing in principal neurons of the medial superior olive. J. Neurosci., 25(35):7887-95