ICLM: Discover, teach, treatI.C. Learning & Memory

Stacks Image 7

Nanthia Suthana

Dr. Suthana’s research uses intracranial single-unit and local field potential recordings combined with deep brain stimulation in neurosurgical patients with electrodes implanted for epilepsy evaluation to investigate the neuronal correlates of learning, memory, and spatial navigation. These studies provide a rare window into human brain function during cognition and how these systems may be modulated to improve function. The Suthana lab also uses non-invasive methods for improving cognitive function such as transcranial magnetic stimulation, electroencephalography, and high-resolution functional magnetic resonance imaging. Lastly, the Suthana laboratory uses Virtual Reality Motion Capture (VR-MoCap) combining sub-millimeter full body motion capture with immersive virtual augmented reality technology in participants who have high-density mobile EEG recording of brain activity and implanted deep brain electrodes for recording and stimulating of brain activity. The overall goal of the VR-MoCap laboratory is to investigate brain mechanisms underlying real-world ambulatory behaviors. Dr. Suthana is also highly involved in increasing educational and career opportunities for women and underrepresented minorities in the STEM fields. She serves as the Associate Director for Outreach for the Brain Research Institute and Assistant Director of Postdoctoral Outreach and Educational Programs.

Recent Publications:

1. Suthana, N., Ekstrom, A., Moshirvaziri, S., Knowlton B., Bookheimer, S.Y. (2009) Human hippocampal CA1 involvement during allocentric encoding of spatial information. Journal of Neuroscience 29:10512-9

2. Suthana, N., Ekstrom, A., Moshirvaziri, S., Knowlton B., Bookheimer, S.Y. (2011) Dissociations within Human Hippocampal Subregions during Encoding and Retrieval of Spatial Information. Hippocampus, 21:694-701

3. Suthana, N., Haneef, Z., Stern, J., Mukamel, R., Behnke, E., Knowlton, B., Fried, I. (2012) Memory Enhancement and Deep Brain Stimulation of Entorhinal Area. New England Journal of Medicine, 366:502-510

4. Suthana, N., Fried, I. (2012) Percepts to recollections: Insight from single neuron recordings in the human brain. Trends in Cognitive Science, 16:427-36, Review

5. Jacobs, J., Weidemann, C., Miller, J., Solway, A., Burke, J., Wei, X., Suthana, N., Sperling, M., Sharan, A., Fried, I., Kahana, M. (2013) Direct recordings of grid-like neuronal activity in human spatial navigation. Nature Neuroscience 16:1188-90

6. Suthana, N. and Fried, I. (2014) Deep Brain Stimulation for Enhancement of Learning and Memory. Review. Neuroimage 85:996-1002, Review

7. Miller, J., Suthana, N., Fried, I., Jacobs, J. (2015) Repeating spatial activations in human entorhinal cortex. Current Biology, 25:1080-5, PMID: 25843029

8. Suthana, N., Parikshak, N., Ekstrom A.D., Ison, M., Knowlton, B., Bookheimer S.Y., Fried, I. (2015) Specific responses of human hippocampal neurons are associated with better memory. Proceedings of the National Academy of Sciences, 112:10503-8, PMID: 26240357