ICLM: Discover, teach, treatI.C. Learning & Memory

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Austin Coley

The Coley laboratory investigates neural populations and dynamics associated with depressive-like behaviors. We apply integrative approaches such as in vivo 2-photon calcium imaging to measure neural activity and population dynamics, and ex vivo electrophysiology to record synaptic properties. We utilize optogenetics techniques to selectively activate neural circuits and assess the response within specific neurons. We also use computer-based tracking systems to monitor behavioral tasks and apply machine learning methods to uncover the relationship between neural activity and behavior. Additionally, we use theoretical and neurocomputational models to further understand neuronal population function in higher-order processing regions.

Recent Publications

Li, H*, Namburi, P*, Olson, J.M.*, Borio, M, Lemieux, M.E., Beyeler, A, Calhoon, G.G., Hitora-Imamura, N, Coley, A.A., Libster, A, Bal, A, Jin, X, Wang, H, Jia, C, Choudhury, S.R., Shi, X, Felix-Ortiz, A.C., De la Fuente, V, Barth, V.P., King, H.O., Izadmehr, E.M., Revanna, J.S., Batra K., Fischer, K.B., Keyes, L.R., Padilla-Coreano, N, Siciliano, C.A., McCullough, K.M., Wichmann, R, Ressler, K.J., Fiete, I.R., Zhang, F, Li, Y, Tye, K.M (2022). Neurotensin orchestrates valence assignment in the amygdala. Nature. doi: 10.1038/s41586-022-04964-y

Coley, A.A.*, Padilla-Coreano, N*, Patel, R*, Tye, K.M (2021). Valence processing in the PFC: reconciling circuit-level and systems-level views. International Review of Neurobiology. doi.org/10.1016/bs.irn.2020.12.002

McEachern, E.P.*, Coley, A.A.*, Yang, S.S., Gao W.J. (2020). “PSD-95 alters GABAergic inhibition in the medial prefrontal cortex.” Neuropharmacology. doi.org/10.1016/j.neuropharm.2020.108277

Coley, A. A. and W.-J. Gao (2019). "PSD-95 deficiency disrupts PFC-associated function and behavior during neurodevelopment." Scientific Reports 9(1): 9486. doi: 10.1038/s41598-019-45971-w; PMCID: PMC6602948

Hill, S.A.*, Blaeser A.*, Coley, A.A., Xie Y., Shepard K.A., Harwell C., Gao W.J., Garcia A.D.R (2019). Sonic hedgehog signaling in astrocytes mediates cell-type-specific synaptic organization. eLife 8: e45545. doi: 10.7554/eLife.45545; PMCID: PMC6629371

Coley, A. A. and W.-J. Gao (2018). "PSD-95: A synaptic protein implicated in schizophrenia or autism?" Progress in Neuro-Psychopharmacology and Biological Psychiatry 82: 187-194. doi: 10.1016/j.pnpbp.2017.11.016; PMCID: PMC5801047