Cellular and Systems Mechanisms of L&M
Siena, Italy
June 2, 2017

Pasted Graphic
June 2, 2017
Howard Eichenbaum
Center for Memory & Brain and Center for Neuroscience
Boston University

1-The hippocampus in time
The hippocampus has long been implicated in spatial mapping and navigation. However, recent evidence indicates that hippocampal neurons also encode the temporal structure of events in memories, suggesting a parallel to spatial information processing in the temporal domain. These and related findings indicate that the hippocampus organizes memories in time in support of its role in our capacity for episodic memory.

2-The organization and control of hippocampal memory representations
Using a representational similarity analysis (RSA) on ensembles of simultaneously recorded neurons combined with analyses of functional connectivity, we can examine the structure of memory representations in the cortical-hippocampal system, including the hippocampus, entorhinal cortex, and prefrontal cortex, and we can determine the flow of information between connected areas. These studies are revealing an elaborate, systematic organization of memories encoded within this system, as well as new insights into how these areas interact to support the retrieval of memory representations.