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Joseph Watson

Joseph Watson's lab is studying how synaptic function is altered in the age-related disorders, including Parkinson’s Disease and Alzheimer’s Disease. They use molecular/ biochemical and electrophysiological studies of synaptic function in vitro in mouse brain slices. The laboratory is also identifying the relevant brain targets of oxidative stress induced by pesticides and herbicides, which are environmental risk factors for Parkinson’s Disease.

Recent Publications


Makhinson, M., Chotiner, J.K., Watson, J.B., and O’Dell, T.J. (1999) Adenylyl cyclase activation modulates activity-dependent changes in synaptic strength and Ca2+/calmodulin-dependent kinase II autophosphorylation. Journal of Neuroscience 19: 2500-2510. PMID: 10087064

 
Watson, J.B., Khorasani, H., Persson, A., Huang, K-P. Huang, F.I., and O’Dell, T.J. (2002) Age-related deficits in long-term potentiation are insensitive to hydrogen peroxide: coincidence with enhanced autophosphorylation of Ca
2+/calmodulin-dependent protein kinase II. Journal of Neuroscience Research 70: 298-308. PMID: 12391589
 
Chotiner, J.K., Khorasani, H., Nairn, A.C., O’Dell, T.J., and Watson, J.B. (2003) Adenylyl cyclase-dependent form of chemical long-term potentiation triggers translational regulation at the elongation step. Neuroscience 116: 743-752. PMID: 12573716
 
Watson, J.B., Arnold, M.M., Ho, Y-S., O’Dell, T.J. (2006) Age-dependent modulation of hippocampal long-term potentiation by anti-oxidant enzymes. Journal of Neuroscience Research 84:1564-1574. PMID: 16941635
 
Watson, J.B. Hatami, A., David, H., Masliah, E., Roberts, K., Evans, C.E., Levine, M.S. (2009) Alterations in corticostriatal synaptic plasticity in mice over-expressing human α-synuclein. Neuroscience 159:501-513. PMID: 19361478
 
Sarafian, T.A, Ryan, C.M, Souda, P., Masliah, E., Kar, UK, Vinters, H.V., Mathern, G.W., Faull, K.F., Whitelegge, J.P., Watson, J.B. (2013) Impairment of mitochondria in adult mouse brain overexpressing predominantly full-length, N-terminally acetylated human α-synuclein.  PLoS ONE 8(5): 1-15. doi: 10.1371/journal.pone.0063557 PMID:23667637