Dale Bredesen studies mechanisms of Alzheimer’s disease and potential therapeutics. The uniform failure of recent drug trials in Alzheimer’s disease has highlighted the critical need for a more accurate understanding of the fundamental nature of Alzheimer’s disease. Dr. Bredesen’s research has led to new insight that explain the erosion of memory seen in Alzheimer’s disease. His laboratory has found evidence that Alzheimer’s disease stems from an imbalance in nerve cell signaling: in the normal brain, specific signals foster nerve connections and memory making, while balancing signals support memory breaking, allowing irrelevant information to be forgotten. But in Alzheimer’s disease, the balance of these opposing signals is disturbed, nerve connections are suppressed, and memories are lost.
Qiang Zhang, Olivier Descamps... Dale E Bredesen "Paradoxical Effect of TrkA Inhibition in Alzheimer's Disease Models." J. Alzheimers Dis. 40:3 605-17
L Galluzzi, J M Bravo-San Pedro... R A F "Essential versus accessory aspects of cell death: recommendations of the NCCD 2015." Cell Death Differ.
Dale E Bredesen, Varghese John... Varghese John "Next generation therapeutics for Alzheimer's disease." EMBO Mol Med 5:6 795-8
Olivier Descamps, Patricia Spilman... Varghese John "AβPP-Selective BACE Inhibitors (ASBI): Novel Class of Therapeutic Agents for Alzheimer's Disease." J. Alzheimers Dis. 37:2 343-55
Veena Theendakara, Alexander Patent... Dale E Bredesen "Neuroprotective Sirtuin ratio reversed by ApoE4." Proc. Natl. Acad. Sci. U.S.A. 110:45 18303-8
Jonathan G Rodríguez Plaza, Amanda Villalón Rojas... Gabriel Del Rio "Correction: Moonlighting Peptides with Emerging Function." PLoS ONE 8:10
Patricia Spilman, Olivier Descamps... Dale E Bredesen "The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model." Brain Res. 1551C 25-44
Sung W Choi, Akos A Gerencser... Martin D Brand "No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease." J. Neurosci. 32:47 16775-84
David T Madden, Diana Davila-Kruger... Dale E Bredesen "Correction: Human Embryonic Stem Cells Express Elevated Levels of Multiple Pro-Apoptotic BCL-2 Family Members." PLoS ONE 7:9
Junli Zhang, Patricia Spilman... Rammohan V Rao "The small co-chaperone p23 overexpressing transgenic mouse." J. Neurosci. Methods 212:2 190-194