Numerous ongoing studies in The Small lab have led to the development of diagnostic tools for early detection of Alzheimer’s disease and other causes of age-related memory loss. Projects target a range of risk factors and populations, including traumatic brain injury in retired athletes and military personnel, as well as brain imaging and genetic measures in individuals at risk for dementia. Longevity Center investigators are testing a variety of interventions—medications, foods, and physical and mental activity—that might protect brain health and delay age-related cognitive decline. These double-blind, placebo-controlled studies focus on people at risk for Alzheimer’s dementia, as well as those already experiencing symptoms.
Roussotte FF, Hua X, Narr KL, Small GW, Thompson PM, for the Alzheimer’s Disease Neuroimaging Initiative. The C677T variant in MTHFR modulates associations between brain integrity, mood, and cognitive functioning in old age. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2017 Apr;2(3):280-288. doi: 10.1016/j.bpsc.2016.09.005.
Burggren AC, Mahmood Z, Harrison TM, Siddarth P, Miller KJ, Small GW, Merrill DA, Bookheimer S. Hippocampal thinning linked to longer TOMM40 poly-T variant lengths in the absence of the APOE ε4 variant. Alzheimers Dement. 2017 Jul;13(7):739-748. doi:10.1016/j.jalz. 2016.12.009. Epub 2017 Feb 7.
Eyre HA, Siddarth P, van Dyk K, St Cyr N, Baune BT, Barrio JR, Small GW, Lavretsky H. Neural correlates of apathy in late-life depression: a pilot [18 F]FDDNP positron emission tomography study. Psychogeriatrics. 2017 May;17(3):186-193. doi: 10.1111/psyg.12213. Epub 2017 Jan 28.
Omalu B, Small GW, Bailes J, Ercoli LM, Merrill DA, Wong K-P, Huang S-C, DSc, Satyamurthy N, Hammers JL, Lee J, Fitzsimmons RP, Barrio JR. Post-mortem autopsy-confirmation of ante-mortem [F-18]FDDNP-PET scans in a football player with chronic traumatic encephalopathy. Neurosurgery. 2018 Feb 1;82(2):237-246. doi: 10.1093/neuros/nyx536.
Roussotte FF, Siddarth P, Merrill DA, Narr KL, Ercoli LM, Martinez J, Emerson ND, Barrio JR, Small GW. In vivo brain plaque and tangle burden mediates the association between diastolic blood pressure and cognitive functioning in non-demented adults. American Journal of Geriatric Psychiatry. 2018 Jan;26(1):13-22. doi: 10.1016/j.jagp.2017.09.001.
Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, Martinez J, Wond K-P, Liu J, Merrill DA, Chen ST, Henning SM, Satyamurthy N, Huang SC, Heber D, Barrio JR. Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults: A double-blind, placebo-controlled 18-month trial. American Journal of Geriatric Psychiatry. 2018; 26:266–277.
McEwen SC, Siddarth P, Abedelsater B, Mui W, Wu P, Donoghue N, Lee J, Greenberg S, Shelton T, Kim Y, Kaiser S, Small G, Merrill D. Simultaneous aerobic exercise and memory training program in older adults with subjective memory impairments. Journal of Alzheimer’s Disease. 2018;62(2):795-806. doi: 10.3233/JAD-170846.
Siddarth P, Rahi B, Emerson ND, Burggren AC, Miller KJ, Bookheimer S, Lavretsky H, Bobkin B, Small G, Merrill DA. Physical activity and hippocampal sub-region structure in older adults with memory complaints. Journal of Alzheimer’s Disease. 2018;61(3):1089-1096. doi: 10.3233/JAD-170586.
Siddarth P, Burggren AC, Eyre HA, Small GW, Merrill DA. Sedentary behavior associated with reduced medial temporal lobe thickness in middle-aged and older adults. PLoS One. 2018 Apr 12;13(4):e0195549. doi: 10.1371/journal.pone.0195549.
Chen ST, Siddarth P, Merrill DA, Martinez J, Emerson ND, Liu J, Wong K-P, Satyamurthy N, Giza GC, Huang S-C, Fitzsimmons RP, Bailes J, Omalu B, Barrio JR, Small GW. FDDNP-PET tau brain protein binding patterns in military personnel with suspected chronic traumatic encephalopathy. Journal of Alzheimer’s Disease. 2018: DOI 10.3233/JAD-171152.
Burggren AC, Siddarth P, Mahmood Z, London E, Harrison TM, Merrill DA, Small GW, Bookheimer SY. Subregional hippocampal thickness abnormalities in older adults with a history of heavy cannabis use. Cannabis Cannabinoid Res 2018 Dec 10;3(1):242-251. doi: 10.1089/can.2018.0035. eCollection 2018.
Siddarth P, Burggren AC, Merrill DA, Ercoli LM, Mahmood Z, Barrio JR, Small GW. Longer TOMM40 Poly-T variants associated with higher FDDNP-PET medial temporal tau and amyloid binding. PLoS One. 2018 Dec 5;13(12):e0208358. doi: 10.1371/journal.pone.0208358. eCollection 2018.