The Masmanidis is interested in understanding the neural basis of simple reward-guided behaviors such as Pavlovian conditioning. They primarily study neural dynamics of corticostriatal circuits, and try to understand how these dynamics are regulated by external inputs and local microcircuits, and their behavioral function. Their approach relies on using silicon microprobe electrode arrays to record the activity of large populations of neurons. They combine large-scale recordings with optogenetic perturbations to determine the contribution of specific circuits on neural dynamics and information processing, and to establish causal links between neural activity and behavior.
Shobe JL, Bakhurin KI, Claar LD, Masmanidis SC. Selective modulation of orbitofrontal network activity during negative occasion setting. Journal of Neuroscience (2017).
Lee K*, Holley SM*, Shobe JL, Chong NC, Cepeda C, Levine MS, Masmanidis SC. Parvalbumin Interneurons Modulate Striatal Output and Enhance Performance during Associative Learning. Neuron (2017).
Bakhurin KI*, Goudar V*, Shobe JL, Claar LD, Buonomano DV, Masmanidis SC. Differential Encoding of Time by Prefrontal and Striatal Network Dynamics. Journal of Neuroscience (2017).
Bakhurin KI, Mac V, Golshani P, Masmanidis SC. Temporal correlations among functionally specialized striatal neural ensembles in reward conditioned mice. Journal of Neurophysiology (2016).
Shobe JL*, Claar LD*, Parhami S, Bakhurin KI, Masmanidis SC. Brain activity mapping at multiple scales with silicon microprobes containing 1024 electrodes. Journal of Neurophysiology (2015).