The Izquierdo lab studies the brain mechanisms of optimal choices. Specifically, this involves exploring the environmental factors that contribute to reward-related decisions and the prediction and calculation of such factors by the organism. The lab also studies the neural basis of emotional decisions and executive function. More recently the Izquierdo lab has investigated the computational modeling of responses to positive and negative feedback, the influence of drugs of abuse on this learning, and the developmental trajectory of choice behavior.
Lab Web site
Izquierdo A, Darling C, Manos N, Pozos H, Kim C, Ostrander S, Cazares V, Stepp H, Rudebeck PH (2013). Basolateral amygdala lesions facilitate reward choices after negative feedback in rats. The Journal of Neuroscience 33(9): 4105-9.
Kosheleff AR, Grimes M, O'Dell SJ, Marshall JF, Izquierdo A (2012). Work aversion and associated changes in dopamine and serotonin transporter after methamphetamine exposure in rats. Psychopharmacology, 219(2): 411-20.
Izquierdo A, Carlos K, Ostrander S, Rodriguez D, McCall-Craddolph A, Yagnik G, Zhou F (2012). Impaired reward learning and intact motivation after serotonin depletion in rats. Behavioural Brain Research, 233(2): 494-9.
Izquierdo A and Belcher AM (2012). Rodent models of adaptive decision making. In: Kobeissy FH (Ed.) Psychiatric Disorders: Methods Mol Biol, Humana Press, New York, 829: 85-101.
Ostrander S, Cazares VA, Kim C, Cheung S, Gonzalez I, Izquierdo A. (2011). Orbitofrontal cortex and basolateral amygdala lesions result in suboptimal and dissociable reward choices on cue-guided effort in rats. In: Baxter, MG (Ed.), Translating Models in Prefrontal Cortex Function between Animals and Humans. Behavioral Neuroscience, 125(3): 350-359.
Izquierdo A, Belcher AM, Scott L, Cazares VA, Chen J, O'Dell SJ, Malvaez M, Wu T, and Marshall JF (2010). Reversal-specific learning impairments following a binge regimen of methamphetamine in rats: Possible involvement of striatal dopamine. Neuropsychopharmacology 35: 505-514.