The Golshani lab is using genetics, in vivo electrophysiological recordings, and two photon confocal imaging to study the cellular and systems mechanisms underlying cortical perception and learning. The laboratory is also interested i studying the cellular and systems mechanisms affected by epilepsy and autism, two conditions that often occur together.
Lab web site: http://golshanilab.neurology.ucla.edu/
Golshani P, Hutnick L, Schweizer F, and Fan G; Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation. Thalamus Related Systems. 2007 March 7th.. (Please note: the date on the online manuscript and on Pubmed is incorrect. The correct date is 2007. Documentation of this date has been provided in the dossier.)
Ranaparkhi R, Lawless GM, Schweizer F, Golshani P, and Jackson GR; A drosophila model of the ALS8-associated mutation of VAPB identifies a dominant negative mechanism. PLOS One 2008 Jun 4;3(6):e2334.
Hutnick LK, Golshani P, Namihira M, Xue Z, Matynia A, Yang XW, Silva AJ, Schweizer FE, Fan G; DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. Human Molecular Genetics 2009; doi: 10.1093/hmg/ddp22
Cheng A, Goncalves JT, Golshani P, Arisaka K, and Portera-Cailliau C; Simultaneous multifocal 2-photon calcium imaging at different cortical depths in vivo with spatiotemporal multiplexing, Nature Methods, Published on-line 01/09/2011.
Golshani P, Goncalves JT, Khoshkhoo S, Mostany R, and Smirnakis S, and Portera-Cailliau C; Internally mediated developmental desynchronization of neocortical network activity. Journal of Neuroscience; Sep 2 ; 29 (35):10890-9, 2009