Christopher Colwell laboratory focuses on understanding the mechanisms underlying circadian rhythms in mammals, using a combination of imaging techniques, electrophysiology, behavior, pharmacology and genetics. Dysfunction in the timing of these daily cycles is often found in a number of neurological and psychiatric disorders.
Regulation of L-type Ca++ currents and process morphology in white matter oligodendrocyte precursor cells by golli-myelin proteins.
Fulton D, Paez PM, Fisher R, Handley V, Colwell CS, Campagnoni AT.
Glia. 2010 Aug 15;58(11):1292-303.
Influence of the estrous cycle on clock gene expression in reproductive tissues: effects of fluctuating ovarian steroid hormone levels.
Nakamura TJ, Sellix MT, Kudo T, Nakao N, Yoshimura T, Ebihara S, Colwell CS, Block GD.
Steroids. 2010 Mar;75(3):203-12. Epub 2010 Jan 22.
Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca2+ influx.
Paez PM, Fulton DJ, Spreuer V, Handley V, Campagnoni CW, Macklin WB, Colwell C, Campagnoni AT.
J Neurosci. 2009 May 20;29(20):6663-76.
Golli protein negatively regulates store depletion-induced calcium influx in T cells.
Feng JM, Hu YK, Xie LH, Colwell CS, Shao XM, Sun XP, Chen B, Tang H, Campagnoni AT.
Immunity. 2006 Jun;24(6):717-27.
Disrupted circadian rhythms in VIP- and PHI-deficient mice.
Colwell CS, Michel S, Itri J, Rodriguez W, Tam J, Lelievre V, Hu Z, Liu X, Waschek JA.
Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R939-49. Epub 2003 Jul 10.